Anti-ageing in C. elegans model, LM, SEM, TEM

Reproductive biology and biomedicine, Effects of stress on epididymal function, Roles of tyrosine phosphorylation in the reproductive system, Effects of medicinal plants on reproductive toxicology

Skeletal studies and histology

• Application of bioactive compounds or Thai herbs, in cardiovascular and urinary researches especially in hypertensive rat model

• Vascular Variation in human cadaver

Dr. Sitthichai Iamsaard is currently an associate professor in the Department of Anatomy, Khon Kaen University, Thailand. He received his BSc degree in animal production technology and PhD degree in anatomy and structural biology at Mahidol University, Thailand. He also received training from Dr. Nongnuj Tanphaichitr, Ottawa Hospital Research Institute as an exchange PhD student for 3.5 years and had a number of publications on the roles of sperm surface enzymes, including PCSK4, in fertilization. His current research activities are twofold. The first is the Routine to Research (R2R), in which his research on human musculoskeletal variations and physical anthropology emerges from his routine teaching duty on gross anatomy. Dr. Iamsaard’s second research aspect is basic science studies on reproductive biomedicine and toxicology. He has described structural and biochemical changes of male reproductive organs in the animal models of DM type 2, chronic stress, and alcoholism as well as animals administered with cancer drugs such as valproic acid (VPA) and ketoconazole. In addition, Dr. Iamsaard is trying to use herbal/traditional medicine in reproductive health intervention. His research is highlighted by the cover photo on his VPA work in a Reproduction, Fertility and Development issue (2017) and his publication on the changes of tyrosine phosphorylated proteins in DM testis being selected as the best paper in International Journal of Reproductive Medicine (2018-2020).

Reproductive biology & toxicity

• Application of bioactive compounds in cardiovascular research in hypertensive rat model 

• Human osteometric study

•  Neuroprotective effect of bioactive compounds from plant (antioxidant, anti-aging)

• Human osteometric study

Application of bioactive compounds from seaweed, in biomedical researches

• Analysis on Fine Structural Basis of Signaling in Cell Activity mainly in tissue cells.

• Electron microscope

• Bioactive compounds from natural products, particularly from seaweed, in biomedical researches (anti-oxidant, anti-aging, anti-cancer, wound healing and immune enhancer)

• Structure activity relationships ofsulfated galactans isolated from Gracilaria fisheri

• Application of bioactive compounds from Herbs, plants, in biomedical researches; antioxidant, anti-aging, anti-inflammation)

• Neurosciences and Neurobehavioral research; Alzheimer, Diabetic and Brain research

• Neurogenesis in the adult and developing brain.

• Neuroprotective effects of bioactive compounds on neurogenesis related   to memory in animal models including aging and antimitotic drugs such as valproic acid, chemotherapeutic drugs and L-methionine.

• Effect of bioactive compounds on regulation of adult hippocampal neural   stem cells in vitro and in vivo.

1. Cadaveric study 

2. Osteometric study

3. Histology and molecular study

4. Proteomic research (LC-MS, MALDI-TOF)

• Morphology changes of dry eyes, Anthropology, Forensic anthropology 

-Cell & Molecular Biology of Cancer

-Natural products research

1. Neurogenesis in the adult and developing brain.

I focus on new neurons that are continually generated throughout adulthood in predominantly two regions of the brain, especially, the subgranular zone (SGZ) of the dentate gyrus in the hippocampus.

2. Application of bioactive compounds from Thai plants in biomedical research.

I am interested in the antioxidant effect of Thai plants on neural stem cells in the hippocampal dentate gyrus that is associated with memory, anti-aging and anti-cancer.

• Human musculoskeletal researches

• Morphological sciences

• Reproductive biology and biomedicine

• Roles of tyrosine phosphorylation in the reproductive system

• Effects of medicinal plants on reproductive toxicology

Our research group is currently focused on investigating essential biomolecules, including diacylglycerol kinase and fatty acid binding protein (both involved in lipid signaling), vesicular inhibitory amino acid transporter (involved in GABA and glycine production/release), cannabinoid receptor 1 (a retrograde messenger receptor), and an exchange factor for ADP ribosylation factor 6 (a key molecule in membrane dynamics) in various peripheral organs. These organs include the salivary gland, kidney, ovary, cardiac muscle, striated muscle, peripheral ganglionic supporting cells, and steroidogenic tissues. We specifically examine the expression and localization of these molecules using a range of advanced techniques, such as immunolight microscopy (immune-LM), immuno-DAB transmission electron microscopy (immune-DAB-TEM), immunonanogold-TEM, western blotting, correlative light and electron microscopy (CLEM), and array tomography with 3D reconstruction. The findings from this research are expected to be critical in further elucidating the functions of each organ and will provide an important foundation for clinically applied research.

• Neurogenesis in the adult and developing brain 

• Neurosciences, Neuroanatomy, and Neurobehavioral research

• Neurogenesis in the adult brain.

• Effect of bioactive compounds on the regulation of hippocampal neurogenesis in vivo and neural stem cells in vitro.

• Neuroprotective effects of bioactive compounds on hippocampal neurogenesis in memory impairment models