1. Neurogenesis in the adult and developing brain.
I focus on new neurons that are continually generated throughout adulthood in predominantly two regions of the brain, especially, the subgranular zone (SGZ) of the dentate gyrus in the hippocampus.
2. Application of bioactive compounds from Thai plants in biomedical research.
I am interested in the antioxidant effect of Thai plants on neural stem cells in the hippocampal dentate gyrus that is associated with memory, anti-aging and anti-cancer.
Aranarochana A, Kaewngam S, Anosri T, Sirichoat A, Pannangrong W, Wigmore P, et al. Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid. Nutrients. 2021;13(12).
Aranarochana A, Sirichoat A, Pannangrong W, Wigmore P, Welbat JU. Melatonin Ameliorates Valproic Acid-Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats. Oxid Med Cell Longev. 2021;2021:9997582.
Sritawan N, Suwannakot K, Naewla S, Chaisawang P, Aranarochana A, Sirichoat A, et al. Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats. Biomed Pharmacother. 2021;144:112280.
Suwannakot K, Sritawan N, Prajit R, Aranarochana A, Sirichoat A, Pannangrong W, Wigmore P, et al. Melatonin protects against the side-effects of 5-fluorouracil on hippocampal neurogenesis and ameliorates antioxidant activity in an adult rat hippocampus and prefrontal cortex. antioxidant 2021; 10, 615. https://doi.org/10.3390/antiox10040615
Sritawan N, Prajit R, Chaisawang P, Sirichoat A, Pannangrong W, Wigmore P, et al. Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model. Biomed Pharmacother. 2020, 22; 131:110651. doi: 10.1016/j.biopha.2020.110651.
Welbat JU, Naewla S, Pannangrong W, Sirichoat A, Aranarochana A, Wigmore P. Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat. Biochem Pharmacol 2020; 178: 114083.
Sirichoat A, Suwannakot K, Chaisawang P, Pannangrong W, Aranarochana A, Wigmore P, et al. Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats. Life Sci 2020; 117468.5.
Prajit R, Sritawan N, Suwannakot K, Naewla S, Aranarochana A, Sirichoat A, et al. Chrysin protects against memory and hippocampal neurogenesis depletion in D-galactose-induced aging in rats. Nutrients 2020; 12.
Sirichoat A, Krutsri S, Suwannakot K, Aranarochana A, Chaisawang P, Pannangrong W, Wigmore P, Welbat JU. Melatonin protects against methotrexate-induced memory deficit and hippocampal neurogenesis impairment in a rat model. Biochemical pharmacology 2019; 163:225-233.
Aranarochana A, Chaisawang P, Sirichoat A, Pannangrong W, Wigmore P, Welbat JU. Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis. Neuroscience 2019; 406:580-593.
Naewla S, Sirichoat A, Pannangrong W, Chaisawang P, Wigmore P, Welbat JU. Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats. Nutrients 2019; 11.
Pannangrong W, Sirichoat A, Wongsiri T, Wigmore P, Welbat JU. Valproic acid withdrawal ameliorates impairments of hippocampal-spatial working memory and neurogenesis. J Zhejiang Univ-Sc B 2019; 20:253-263.
Chaisawang, P., A. Sirichoat, W. Chaijaroonkhanarak, W. Pannangrong, B. Sripanidkulchai, P. Wigmore and J. U. Welbat. "Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy." PLoS One 2017; 12(7): e0180650.