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รศ.ดร.วิภาวี หีบแก้ว

Wiphawi Hipkaeo, Assoc. Prof., Ph.D.

รศ.ดร.วิภาวี หีบแก้ว

Research Interest

Our research group is currently focused on investigating essential biomolecules, including diacylglycerol kinase and fatty acid binding protein (both involved in lipid signaling), vesicular inhibitory amino acid transporter (involved in GABA and glycine production/release), cannabinoid receptor 1 (a retrograde messenger receptor), and an exchange factor for ADP ribosylation factor 6 (a key molecule in membrane dynamics) in various peripheral organs. These organs include the salivary gland, kidney, ovary, cardiac muscle, striated muscle, peripheral ganglionic supporting cells, and steroidogenic tissues. We specifically examine the expression and localization of these molecules using a range of advanced techniques, such as immunolight microscopy (immune-LM), immuno-DAB transmission electron microscopy (immune-DAB-TEM), immunonanogold-TEM, western blotting, correlative light and electron microscopy (CLEM), and array tomography with 3D reconstruction. The findings from this research are expected to be critical in further elucidating the functions of each organ and will provide an important foundation for clinically applied research.

Publications

การแต่งหนังสือ [ตั้งแต่ ปี: พ.ศ. 2563 (ค.ศ. 2020) เป็นต้นไป]

1.วิภาวี หีบแก้ว. ศักยะแห่งกล้องจุลทรรศน์อิเล็กตรอน. 2566, 183 หน้า โรงพิมพ์ ดีเซมเบอรี่ กรุงเทพมหานคร  ISBN 978-616-598-240-5.



ผลงานวิจัยตีพิมพ์ใน Journal ระดับนานาชาติ ในฐาน Scopus [ตั้งแต่ ปี: พ.ศ. 2563 (ค.ศ. 2020) เป็นต้นไป]

2024

1.Chomphoo S, Sakagami H, Kondo H, Hipkaeo W. Localization of EFA6A, an exchange factor for Arf6, in Z-lines and sarcoplasmic reticulum membranes in addition to myofilaments in I-domains of skeletal myofibers of peri-natal mice. Acta Histochem. 2024 Aug 9;126(5-7):152187. doi: 10.1016/j.acthis.2024.152187. Epub ahead of print. PMID: 39126836.

2.Chomphoo S, Kondo H, Hipkaeo W. Electron-translucency and partial defects of synaptic basal lamina in the electrocyte synapse of an electric ray (Narke japonica) in 3D embedment-free section electron microscopy. Microsc Res Tech. 2024 Jul;87(7):1647-1653. doi: 10.1002/jemt.24534. Epub 2024 Mar 10. PMID: 38461470.

3.Ratchatasunthorn A, Sakagami H, Kondo H, Hipkaeo W, Chomphoo S. Temporal involvement of phosphatidylinositol 4-phosphate 5-kinase γ in differentiation of Z-bands and myofilament bundles as well as intercalated discs in mouse heart at mid-gestation. J Anat. 2024. doi: 10.1111/joa.14008. Advance online publication. https://doi.org/10.1111/joa.14008.


2023

4.Hipkaeo W*, Kondo H. Localization of phospholipid-related signal molecules in salivary glands of rodents: A review. J Oral Biosci. 2023;65(2):146–155. https://doi.org/10.1016/j.job.2023.04.004.

5.Hemha P, Chomphoo S, Polsan Y, Goto K, Kondo H, Hipkaeo W*. Localization of Diacylglycerol Kinase ζ in the Kidney of Adult Rats: Its Dominant Expression in Collecting Tubules and its Selective Lack in Proximal Tubules. Int J Morphol. 2023;1(2):2.

6.Pakkarato S, Sakagami H, Watanabe M, Kondo H, Hipkaeo W*, Chomphoo S. Discrete localization patterns of PIP5Kγ and PLCβ3 working sequentially in phosphoinositide-cycle within mouse sensory neuron somata. Microsc Res Tech. 2023;86(3):351–358. https://doi.org/10.1002/jemt.24276.

7.Hemha P, Chomphoo S, Polsan Y, Goto K, Watanabe M, Kondo H, Hipkaeo W*. Discrete localization of phospholipase Cβ3 and diacylglycerol kinase ι along the renal proximal tubules of normal rat kidney and gentamicin-induced changes in their expression. Histochem Cell Biol. 2023;159(3):293–307. https://doi.org/10.1007/s00418-022-02166-1.

8.Khrongyut S, Pakkarato S, Watthanakitphibun A, Pidsaya A, Banno Y, Nozawa Y, Kondo H, Hipkaeo W, Chomphoo S. Expression with early postnatal peak and female-dominant sexual dimorphism of phospholipase D (PLD) 2 in submandibular gland ducts in situ of mice. Odontology. 2023;111(3):565–572. https://doi.org/10.1007/s10266-022-00765-x.

9.Singdam P, Naowaboot J, Senggunprai L, Boonloh K, Hipkaeo W, Pannangpetch P. The mechanisms of neochlorogenic acid (3-Caffeoylquinic acid) in improving glucose and lipid metabolism in rats with insulin resistance induced by a high fat-high fructose diet. Trends Sci. 2023; n. pag.


2022

10.Pakkarato S, Sakagami H, Goto K, Watanabe M, Kondo H, Hipkaeo W, Chomphoo S. Localization of phosphatidylinositol phosphate 5 kinase γ, phospholipase β3 and diacylglycerol kinase ζ in corneal epithelium in comparison with conjunctival epithelium of mice. Exp Eye Res. 2022;223:109205. https://doi.org/10.1016/j.exer.2022.109205.

11.Sakaew W, Phanphak J, Somintara S, Hipkaeo W, Wongprasert K, Kovensky J, Pariwatthanakun C, Rudtanatip T. Increased sulfation in Gracilaria fisheri sulfated galactans enhances antioxidant and antiurolithiatic activities and protects HK-2 cell death induced by sodium oxalate. Mar Drugs. 2022 Jun 7;20(6):382. doi: 10.3390/md20060382.

12.Kamnate A, Sirisin J, Watanabe M, Kondo H, Hipkaeo W, Chomphoo S. Mitochondrial localization of CB1 in progesterone-producing cells of ovarian interstitial glands of adult mice. J Histochem Cytochem. 2022 Mar;70(3):251-257. doi: 10.1369/00221554211063516. Epub 2021 Dec 17. PMID: 34915761; PMCID: PMC8832628.


2021

13.Sirisin J, Kamnate A, Polsan Y, Somintara S, Champhoo S, Sakagami H, Kondo H, Hipkaeo W*. Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K)α confined to the surface of lipid droplets and adjacent narrow cytoplasm in progesterone-producing cells of in situ ovaries of adult mice. Acta Histochem. 2021;123:151794. https://doi.org/10.1016/j.acthis.2021.151794.

14.Chomphoo S, Sakagami H, Kondo H, Hipkaeo W. Localization of PIP5Kγ selectively in proprioceptive peripheral fields and also in sensory ganglionic satellite cells as well as neuronal cell membranes and their central terminals. J Anat. 2021 Nov;239(5):1196-1206. doi: 10.1111/joa.13491. Epub 2021 Jun 20. PMID: 34151437; PMCID: PMC8546504.

15.Phuapittayalert L, Tanasrivaroottanun N, Hipkaeo W, Supanpaiboon W, Sakulsak N. Increased expression of apoptotic markers in human full-term placenta after exposure to elevated environmental cadmium levels during pregnancy. Environ Sci Pollut Res Int. 2021 Oct;28(37):51795-51807. doi: 10.1007/s11356-021-14431-2. Epub 2021 May 15. PMID: 33991298.

16.Kamnate A, Sirisin J, Polsan Y, Chomphoo S, Watanabe M, Kondo H, Hipkaeo W*. In situ localization of diacylglycerol lipase α and β producing an endocannabinoid 2-arachidonoylglycerol and of cannabinoid receptor 1 in the primary oocytes of postnatal mice. J Anat. 2021 Jun;238(6):1330-1340. doi: 10.1111/joa.13392. Epub 2021 Jan 4. PMID: 33398893; PMCID: PMC8128768.

17.Pidsaya A, Hipkaeo W, Kondo H, Pilakasiri K. Spatio-temporally differential expression of HER (human epithelial growth factor receptor)-2 in the acinus and various portions of the ductal system, and its ultrastructural localization in the submandibular gland in situ of postnatal mice. Int J Morphol. 2021;39(5).


2020

18.Pidsaya A, Kamnate A, Sirisin J, Watanabe M, Kondo H, Hipkaeo W*. Different expression and subcellular localization of vesicular inhibitory amino acid transporter in ducts of major salivary glands: An in situ study in mice. Arch Oral Biol. 2020 May;113:104689. doi: 10.1016/j.archoralbio.2020.104689.

19.Chomphoo S, Sakagami H, Kondo H, Hipkaeo W*. Discrete localization patterns of Arf6, and its activators EFA6A and BRAG2, and its effector PIP5kinaseγ on myofibrils of myotubes and plasma membranes of myoblasts in developing skeletal muscles of mice. Acta Histochem. 2020 Apr;122(3):151513. doi: 10.1016/j.acthis.2020

20.Rawangwong A, Watanabe M, Kondo H, Hipkaeo W*. Expression and localization of endogenous phospholipase Cβ3 confined to basal cells in situ of immature ducts and adult excretory ducts of submandibular gland of mice. Acta Histochem. 2020 Feb;122(2):151497. doi: 10.1016/j.acthis.2019.151497.

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